Edward M. Treadwell, Ph.D.
B.S., University of Michigan - Dearborn, 1993
M.S., University of Alaska - Fairbanks, 1996
Ph.D., University of Iowa, 2001
CHM 2040 - Practical Chemistry
CHM 2430 - Survey of Organic Chemistry
CHM 2435 - Organic Chemistry Laboratory
CHM 2440 - Organic Chemistry I
CHM 2445 - Organic Chemistry Laboratory I
CHM 2840 - Organic Chemistry II
CHM 2845 - Organic Chemistry Laboratory II
CHM 4790 - Medicinal Chemistry
CHM 4915 - Advanced Laboratory
CHM 5050 - Organic Chemistry for HS Teachers
CHM 5400 - Physical Organic Chemistry
CHM 5410 - Organic Reactions and Mechanisms
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My research group centers on the development of new synthetic methodologies and their application to the total synthesis of natural products. At the moment, we are exploring monocondensation reactions of the bisphosphonate of acetone (1), which have not been previously reported. While sequential monocondensation reactions will allow access to acyclic dienones (2), a more intriguing application for the bisphosphonate is in the construction of polycyclic compounds with an a-alkylidenyl-b-oxocyclopentyl moiety (4) from cycloalkanones.
After the optimization and definition of the scope of these reactions, we plan to apply this methodology to the total synthesis of biologically active natural products such as the stelletins. We are just beginning our research this year (a very exciting time!), and the group at the moment consists of two undergraduate students and myself. While I have been successful in securing some internal grants, initial external funding from sources such as the Research Corporation are being actively pursued. Feel free to stop by my office or e-mail me for further information.